Membrane-bound carbonic anhydrase CAIV in the human kidney. Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1a stabilization: a role for phosphatidylinositol 3′-kinase. The cytosolic CAIII isoform that is abundantly expressed in skeletal muscle and adipose tissue and to a lesser extent in brain and liver, exhibits the lowest hydratase activity of the CA isoforms (see. Carbonic anhydrase is a zinc metalloenzyme widely distributed throughout the tissues of the body. Evidence for a membrane carbonic anhydrase IV anchored by its C-terminal peptide in normal human pancreatic ductal cells. Direct extracellular interaction between carbonic anhydrase IV and the human NBC1sodium/ bicarbonate co-transporter. Functional consequences of engineering the hydrophobic pocket of carbonic anhydrase II. Carbonic anhydrase (CA) catalyzes the reversible hydration of CO2. Secretion of carbonic anhydrase isoenzyme VI (CAVI) from human and rat lingual serous von Ebner's glands. CAII also associates with NHE1, a ubiquitously expressed glycoprotein that protects cells from intracellular acidification by exchanging one intracellular proton for one extracellular sodium. Localization of carbonic anhydrase IV in rat and human heart muscle. The catalytic mechanism of carbonic anhydrases: implications of rate-limited protolysis of water. Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification. 2020 Dec;9(2):333-347. doi: 10.1007/s40119-020-00194-3. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel–Lindau transgenes. This site needs JavaScript to work properly. Slc26a6: a cardiac chloride-hydroxyl exchanger and predominant chloride-bicarbonate exchanger of the mouse heart. Carbonic anhydrase histochemistry in rabbit and mouse kidneys. Complete amino acid sequence of ovine salivary carbonic anhydrase. Ito Y, Kobayashi S, Nakamura N, Miyagi H, Esaki M, Hoshijima K, Hirose S. Front Physiol. Activity and distribution in male and female metanephros. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. Metabolon disruption: a mechanism that regulates bicarbonate transport. CAIX is abundantly expressed in the proximal gastrointestinal tract including the stomach and gall bladder but not in normal kidney. Physiology and molecular biology of renal carbonic anhydrase. A novel carbonic anhydrase II binding site regulates NHE1 activity. Membrane specific carbonic anhydrase (CAIV) expression in human tissues. Most GPI-anchored proteins are targeted to the apical membrane of polarized epithelial cells. A complementary DNA sequence for a novel CA isoform, CAXV, was submitted to the NCBI in 2000 (GenBank® accession no. COVID-19 is an emerging, rapidly evolving situation. Characterization of CAXV, a new GPI-anchored form of carbonic anhydrase. Localization and activity of renal carbonic anhydrase (CA) in CA-II deficient mice. Carbonic anhydrase in the metanephrogenic zone of the human fetal kidney. Two distinct isozymes of carbonic anhydrase have now been identified in the mammalian kidney. Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. By continuing you agree to the, The role of carbonic anhydrases in renal physiology, View Large This enzyme exists in a number of isozymic forms in most mammalian species. CAIV expressed in basolateral and apical membranes from kidney cortex were equally sensitive to phosphatidylinositol-dependent phospholipase C (PI-PLC) cleavage (see. Epub 2020 Aug 9. The Editorial Review examines the biochemical and morphological approaches that have been used to elucidate the nature of renal carbonic anhydrase and to assess its distribution along the urinary tubule. Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI. Get the latest research from NIH: The amino-acid residues adjacent to His-64 also influence CAII activity. It has been proposed that CAIX activity facilitates the acidification of extracellular milieu surrounding cancer cells by converting CO, Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells, Co-expression and association of CAs with transporters markedly enhances H, Ectopic expression of CAIX in RCC may enable tumor cells to survive and proliferate in hypoxic acidic environments by facilitating H. Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. There are now five membrane-associated CA isoforms with the recent addition of CAXV to this group. Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte Cl. DOI: Studies within the last 10 years have demonstrated that CAs associate with acid/base transporters to form H. To date 15 CA isoforms have been identified of which twelve are catalytically active; CAs VIII, X, and XI are CA-related proteins that are not catalytically active owing to the absence of one or more of the conserved histidine residues that are required for coordination of Zn, which is essential for CA enzyme catalysis. Metabolic acidosis stimulates carbonic anhydrase activity in rabbit proximal tubule and medullary collecting duct. Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer. NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase. Facilitation of kNBC1-mediated bicarbonate transport by CAII was demonstrated in mouse proximal convoluted cell line cell transfectants in which mutations of the two putative CAII binding sites in kNBC1 exhibited a positive correlation between CAII binding and flux inhibition by acetazolamide. In mice, human, and rabbit species, CAXIV is abundantly expressed in heart, skeletal muscle, liver, and in mice and humans abundant expression was also observed in brain.

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